CHALLENGE:
To rescue a CRO managed trial that was severely behind plan having only enrolled half of the patients it needed. The client sought a data-led approach to determine the best course of action.
SOLUTION:
Conducted a deep analysis using the Phesi Trial Accelerator™ platform driven by the world’s largest trial database.
- No major protocol design defects were noted.
- Phesi scenario modeling showed the optimal number of trial sites to be 142.
- The CRO had already activated 200 sites resulting in inadequate support for sites with the biggest potential to enroll.
- Phesi predicted that 60 sites would contribute the majority of patients.
- By monitoring performance against pre-defined parameters and immediately closing sites that had failed to contribute anything for more than 150 days, the optimal number of sites was achieved.
THE DATA:
IMPACT:
As Phesi predicted, enrollment cycle time was reduced with the trial completed in 27 months resulting in a Gross Site Enrollment Rate of 0.12 pts/site/month.
The client’s procurement function reported that Phesi saved more than $5 million through its analysis, “what if” scenario modeling and a 25% reduction in sites.
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